54. Proteasome inhibition suppresses the induction of lipocalin-2 upon systemic lipopolysaccharide challenge in mice
Jin-Sil Bae, Ji-Eun Heo, Kwon-Yul Ryu
53. Recent progress and future directions of the research on nanoplastic-induced neurotoxicity
Seung-Woo Han, Jinhee Choi, Kwon-Yul Ryu
52. Mild oxidative stress induced by sodium arsenite reduces lipocalin-2 expression levels in cortical glial cells
Ye-Jin Cho, So-Hyun Park, Kwon-Yul Ryu
51. Lipocalin-2: a therapeutic target to overcome neurodegenerative diseases by regulating reactive astrogliosis
Byung-Kwon Jung, Kwon-Yul Ryu
50. Alleviation of neurotoxicity induced by polystyrene nanoplastics by
increased exocytosis from neurons
Seung-Woo Han, Taek-Yeong Kim, Jin-Sil Bae, Jinhee Choi, Kwon-Yul Ryu
49. Reduced secretion of LCN2 (lipocalin 2) from reactive astrocytes through autophagic and proteasomal regulation alleviates inflammatory stress and neuronal damage
increased exocytosis from neurons
Byung-Kwon Jung, Yujin Park, Boran Yoon, Jin-Sil Bae, Seung-Woo Han, Ji-Eun Heo, Dong-Eun Kim, Kwon-Yul Ryu
48. Increased clearance of non-biodegradable polystyrene nanoplastics by exocytosis through inhibition of retrograde intracellular transport
increased exocytosis from neurons
Seung-Woo Han, Kwon-Yul Ryu
47. Free ubiquitin: a novel therapeutic target for neurodegenerative diseases
Chul-Woo Park, Kwon-Yul Ryu
46. Polyubiquitin gene Ubb is required for upregulation of Piwi protein level during mouse testis development
Bitnara Han, Byung-Kwon Jung, So-Hyun Park, Kyu Jin Song, Muhammad Ayaz Anwar, Kwon-Yul Ryu, Kwang Pyo Kim
45. Regulation of polyubiquitin genes to meet cellular ubiquitin requirement
Seung-Woo Han, Byung-Kwon Jung, Kwon-Yul Ryu
44. Stress response of mouse embryonic fibroblasts exposed to polystyrene nanoplastics
Seung-Woo Han, Jinhee Choi, Kwon-Yul Ryu
43. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Daniel J. Klionsky, …, Kwon-Yul Ryu, …, Chun-Kit Tong
42. Neurotoxic potential of polystyrene nanoplastics in primary cells originating from mouse brain
Byung-Kwon Jung, Seung-Woo Han, So-Hyun Park, Jin-Sil Bae, Jinhee Choi, Kwon-Yul Ryu
41. Simultaneous disruption of both polyubiquitin genes affects proteasome function and decreases cellular proliferation
Chul-Woo Park, Jin-Sil Bae, Kwon-Yul Ryu
40. Reduced free ubiquitin levels and proteasome activity in cultured neurons and brain tissues treated with amyloid beta aggregates
Chul-Woo Park, Byung-Kwon Jung, Kwon-Yul Ryu
39. Disruption of the polyubiquitin gene Ubb reduces the self-renewal capacity of neural stem cells
Chul-Woo Park, Byung-Kwon Jung, Kwon-Yul Ryu
38. Integrin αvβ3-Akt signalling plays a role in radioresistance of melanoma
Hyuntaik Im, Jeeyong Lee, Kwon-Yul Ryu, Jae Youn Yi
37. Reversible regulation of polyubiquitin gene UBC via modified inducible CRISPR/Cas9 system
Seung-Woo Han, Byung-Kwon Jung, So-Hyun Park, Kwon-Yul Ryu
36. Disruption of the polyubiquitin gene Ubb causes retinal degeneration in mice
Daehan Lim, Chul-Woo Park, Kwon-Yul Ryu, Hyewon Chung
35. Cytoprotective role of ubiquitin against toxicity induced by polyglutamine-expanded aggregates
Jin-Sil Bae, Kwon-Yul Ryu
34. Temporal downregulation of the polyubiquitin gene Ubb affects neuronal differentiation, but not maturation, in cells cultured in vitro
Byung-Kwon Jung, Chul-Woo Park, Kwon-Yul Ryu
33. Effect of p62/SQSTM1 polyubiquitination on its autophagic adaptor function and cellular survival under oxidative stress induced by arsenite
Hyuna Lee, Mi-Nam Kim, Kwon-Yul Ryu
32. A gold nanoparticle-mediated rapid in vitro assay of anti-aggregation reagents for amyloid β and its validation
Hye Young Kim, Donghee Lee, Kwon-Yul Ryu, Inhee Choi
31. Regulation of REST levels overcomes dysregulation of neural stem cell differentiation caused by disruption of polyubiquitin gene Ubb
Minji Kim, Kwon-Yul Ryu
30. Effect of cellular ubiquitin levels on the regulation of oxidative stress response and proteasome function via Nrf1
Donghee Lee, Kwon-Yul Ryu
29. Ubiquitin homeostasis: from neural stem cell differentiation to neuronal development
Han-Wook Ryu, Kwon-Yul Ryu
28. Disruption of polyubiquitin gene Ubc leads to attenuated resistance against arsenite-induced toxicity in mouse embryonic fibroblasts
Mi-Nam Kim, Juhee Choi, Han-Wook Ryu, Kwon-Yul Ryu
27. Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes parkin mitochondrial tethering
Kahori Shiba-Fukushima, Taku Arano, Gen Matsumoto, Tsuyoshi Inoshita, Shigeharu Yoshida, Yasushi Ishihama, Kwon-Yul Ryu, Nobuyuki Nukina, Nobutaka Hattori, Yuzuru Imai
26. Disruption of polyubiquitin gene Ubb causes dysregulation of neural stem cell differentiation with premature gliogenesis
Han-Wook Ryu, Chul-Woo Park, Kwon-Yul Ryu
25. Restoration of cellular ubiquitin reverses impairments in neuronal development caused by disruption of the polyubiquitin gene Ubb
Han-Wook Ryu, Chul-Woo Park, Kwon-Yul Ryu
24. Cellular ubiquitin pool dynamics and homeostasis
Chul-Woo Park, Kwon-Yul Ryu
23. Disruption of polyubiquitin gene Ubc leads to defective proliferation of hepatocytes and bipotent fetal liver epithelial progenitor cells
Hyejin Park, Min-Sik Yoon, Kwon-Yul Ryu
22. Perturbation of the hematopoietic system during embryonic liver development due to disruption of polyubiquitin gene Ubc in mice
Kwon-Yul Ryu, Hyejin Park, Derrick J Rossi, Irving L Weissman, Ron R Kopito
21. Locus coeruleus neurons are resistant to dysfunction and degeneration by maintaining free ubiquitin levels although total ubiquitin levels decrease upon disruption of polyubiquitin gene Ubb
Chul-Woo Park, Han-Wook Ryu, Kwon-Yul Ryu
20. Altered testicular gene expression patterns in mice lacking the polyubiquitin gene Ubb
Shamim A Sinnar, Christopher L Small, Ryan M Evanoff, Laura G Reinholdt, Michael D Griswold, Ron R Kopito, Kwon-Yul Ryu
19. Quantification of oxidative stress in live mouse embryonic fibroblasts by monitoring the responses of polyubiquitin genes
Han-Wook Ryu, Kwon-Yul Ryu
18. Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection
Brigit E Riley, Stephen E Kaiser, Thomas A Shaler, Aylwin C Y Ng, Taichi Hara, Mark S Hipp, Kasper Lage, Ramnik J Xavier, Kwon-Yul Ryu, Keiko Taguchi, Masayuki Yamamoto, Keiji Tanaka, Noboru Mizushima, Masaaki Komatsu, Ron R Kopito
17. Loss of polyubiquitin gene Ubb leads to metabolic and sleep abnormalities in mice
Kwon-Yul Ryu, Nobuhiro Fujiki, Melissa Kazantzis, Jacob C Garza, Donna M Bouley, Andreas Stahl, Xin-Yun Lu, Seiji Nishino, Ron R Kopito
16. The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse models of Huntington’s disease
John S Bett, Caroline L Benn, Kwon-Yul Ryu, Ron R Kopito, Gillian P Bates
15. Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene
Kwon-Yul Ryu, Jacob C Garza, Xin-Yun Lu, Gregory S Barsh, Ron R Kopito
Proceedings of the National Academy of Sciences of the United States of America
, 2008
, 105(10)
, 4016–4021
, Link
14. The mouse polyubiquitin gene Ubb is essential for meiotic progression
Kwon-Yul Ryu, Shamim A Sinnar, Laura G Reinholdt, Sergio Vaccari, Susan Hall, Manuel A Garcia, Tatiana S Zaitseva, Donna M Bouley, Kim Boekelheide, Mary Ann Handel, Marco Conti, Ron R Kopito
13. Global changes to the ubiquitin system in Huntington’s disease
Eric J Bennett, Thomas A Shaler, Ben Woodman, Kwon-Yul Ryu, Tatiana S Zaitseva, Christopher H Becker, Gillian P Bates, Howard Schulman, Ron R Kopito
12. The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance
Kwon-Yul Ryu, René Maehr, Catherine A Gilchrist, Michael A Long, Donna M Bouley, Britta Mueller, Hidde L Ploegh, Ron R Kopito
11. Ubiquitin-specific protease 2 as a tool for quantification of total ubiquitin levels in biological specimens
Kwon-Yul Ryu, Rohan T Baker, Ron R Kopito
10. Signaling through 3’, 5’-cyclic adenosine monophosphate and phosphoinositide-3-kinase induces sodium/iodide symporter expression in breast cancer
Katherine A B Knostman, Je-Yoel Cho, Kwon-Yul Ryu, Xiaoqin Lin, James A McCubrey, Timothy Hla, Catherine H Liu, Emma Di Carlo, Ruth Keri, Ming Zhang, Dae Y Hwang, William C Kisseberth, Charles C Capen, Sissy M Jhiang
9. Application of the Cre/loxP system to enhance thyroid-targeted expression of sodium/iodide symporter (NIS)
Xiaoqin Lin, Andrew H Fischer, Kwon-Yul Ryu, Je-Yoel Cho, Thomas J Sferra, Richard T Kloos, Ernest L Mazzaferri, Sissy M Jhiang
8. Cloning of the 5’-flanking region of mouse sodium iodide symporter and identification of a thyroid-specific and TSH-responsive enhancer
Xiaoqin Lin, Kwon-Yul Ryu, Sissy M Jhiang
7. Development of reverse transcription-competitive polymerase chain reaction method to quantitate the expression levels of human sodium iodide symporter
Kwon-Yul Ryu, Molly E Senokozlieff, Patricia A Smanik, Mariwil G Wong, Allan E Siperstein, Quan-Yang Duh, Orlo H Clark, Ernest L Mazzaferri, Sissy M Jhiang
6. An immunohistochemical study of Na+/I- symporter in human thyroid tissues and salivary gland tissues
Sissy M Jhiang, Je-Yoel Cho, Kwon-Yul Ryu, Barry R DeYoung, Patricia A Smanik, Violeta R McGaughy, Andrew H Fischer, Ernest L Mazzaferri
5. Promoter characterization of the human Na+/I- symporter
Kwon-Yul Ryu, Qiang Tong, Sissy M Jhiang
4. Promoter characterization of the rat Na+/I- symporter gene
Qiang Tong, Kwon-Yul Ryu, Sissy M Jhiang
3. Expression, exon-intron organization, and chromosome mapping of the human sodium iodide symporter
Patricia A Smanik, Kwon-Yul Ryu, Karl S Theil, Ernest L Mazzaferri, Sissy M Jhiang
2. Cloning of the human sodium iodide symporter
Patricia A Smanik, Qingrong Liu, Tara L Furminger, Kwon-Yul Ryu, Shunhua Xing, Ernest L Mazzaferri, Sissy M Jhiang
1. Purification and characterization of farnesyl protein transferase from bovine testis
Kwon-Yul Ryu, Young-Jin Baik, Chul-Hak Yang
