Welcome to Cell Biology Lab

The cell biology laboratory aims to understand the maintenance and disruption of neuronal integrity, as well as the occurrence of neuronal loss during aging. In light of the deterioration of cellular quality control systems, such as the ubiquitin-proteasome system and autophagy-lysosome pathway, during aging, our particular focus lies on these two pathways. The objective is to identify preventive measures against neuronal loss, a phenomenon observed in various neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. To address these inquiries, our laboratory employs genetic, biochemical, cell biological, and organismal approaches. With expertise in working with mouse models and primary cells derived from them, we conduct research with the following keywords: (1) neurodegenerative diseases, (2) reactive astrogliosis, (3) ubiquitin-proteasome system, and (4) autophagy-lysosome pathway.