Ryu Kwon-Yul - Professor - Members - 서울시립대 생명과학과 세포생물학 실험실

서울시립대 자연과학대학 생명과학과

• Lab : 2-225호

• Lab Tel : 02-6490-5628

• Office : 2-218호

• Office Tel : 02-6490-2674

• E-mail : kyryu@uos.ac.kr

New paradigm to develop a therapeutic strategy to overcome neurodegenerative diseases
− Modulation of reactive astrocytes to protect neurons
− Early prediction of neurodegeneration based on reactive astrogliosis
− Development of drugs to alter the activation status of astrocytes
Behaviors and effects of non-biodegradable nanoplastics inside cells
− Assessment of neurotoxicity from inhaled nanoplastics
− Monitoring entry, intracellular movement, and exit of nanoplastics
− Effects intracellular nanoplastics on autophagic and lysosomal machineries
Role of ubiquitin in maintaining cellular homeostasis against proteotoxic stress
− Effects of ubiquitin deficiency on cellular function and viability
− Sensing mechanism of cellular free ubiquitin levels
− Regulation of ubiquitin pool dynamics and ubiquitin genes to increase available free ubiquitin levels
In-depth characterization of animal models with ubiquitin deficiency
− Relationship between early-onset reactive astrogliosis and late-onset neurodegeneration
− Application of therapeutic strategy to rescue phenotypes of ubiquitin-deficient mice
− Establishment of animal models to study reactive astrocyte-mediated neurodegeneration

1995.09 ~ 2001.06 박사: 오하이오 주립대학교, 생화학프로그램 (Ohio State Biochemistry Program)
- 학위논문: “Regulatory mechanisms of the sodium iodide symporter”
1992.03 ~ 1994.02 석사: 서울대학교, 화학과
- 학위논문: “Purification and characterization of farnesyl protein transferase from bovine testis”
1987.03 ~ 1992.02 학사: 서울대학교, 화학과

Professor