Structural Biology Laboratory (구조생물학 실험실)
: Determination of macromolecular structures using Xray crystallography
Our lab is intersted in determining protein and protein complexes including protein/nucleic acid, protein/small molcole complexes. Our research interests include,
- (1) Proteins involved in human innate immune responses and signaling (ex. Toll-like receptors (TLRs), Adaptor proteins for TLR signaling (MyD88, TRAM, TIRAP, TRIF), RIG-I, MDA5 and ZAP)
- (2) Mechanism of viral evasion of innate immune systems (ex. HCV NS5A and Vaccinia virus A46)
- (3) Bacterial proteins in diverse function (ex. Elongation factor P from Pseudomonas aeruginosa,Pseudomonas aeruginosa PA2196, TetR family transcriptional repressor, Bacillus subtilis HmoB, a heme oxygenase)
- (4) Crystallization using gold nanoparticles by inducing crystal nucleation (ex.Use of gold nano particles coated with NTA group for crystallization of his-tagged proteins)
