구조생물학 실험실

서울시립대학교 생명과학과

Structural Biology Laboratory

University Of Seoul

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Welcome to Structural Biology Lab

In our research laboratory, we are utilizing X-ray crystallography to elucidate the three-dimensional structures of proteins. Using this technique, we aim to comprehend the enzymatic mechanisms, ligand recognition methods of receptor proteins, and the principles underlying the interactions of signaling proteins, from both physical and chemical perspectives.

Our major research focus includes determination of 3-dimensional structures and functional studies of proteins that play important roles in the human innate immune system and bacterial proteins with diverse functions.

Latest Publications more +

Crystallization and biochemical studies of the NYN domain of human KHNYN
Sunho Hong , Jungwoo Choe
Acta Crystallogr F Struct Biol Commun ., 2024, 80, 67-72 Link
Photothermally-modulated Intracellular Delivery of Therapeutic Proteins using Gold-Collagen Hybrid Nanoparticles
Doyun Kim, Seungki Lee, Donghun Shin, Sunho Hong, Sangkyu Park, Jungwoo Choe, Jeong-Min Seo, Jong Bum Lee, Inhee Choi
ACS Materials Letters, 2023, 6(2), 409-417 Link
Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia
Moon Y, Chae S, Yim S, Yang EG, Choe J, Hyun J, Chang R, Hwang D, Park H.
iScience, 2022, 25(7), 104517 Link
Structural and Biochemical Studies of Bacillus subtilis MobB
Kim, D., Choi, S., Kim, H., Choe, J.
Crystals, 2021, 11 (10), 1262 Link
Induction of crystal nucleation by orientation-controlled binding of His6-tagged proteins to functionalized gold nanoparticles
Park, J., Kang, T.H., Choi, I., Choe, J.
CrystEngComm, 2020, 22 (6), 1032-1040 Link
Crystal Structures of Putative Flavin Dependent Monooxygenase from Alicyclobacillus Acidocaldarius
Moon, H., Shin, S., Choe, J.
Crystals, 2019, 9 (11), 548 Link
Crystal structure of Pseudomonas aeruginosa N-acetyltransferase PA4534
Shin, S., Choe, J.
Biochemical and Biophysical Research Communications, 2017, 487 (2), 236-240 Link
Gold Nanoparticles as Nucleation-Inducing Reagents for Protein Crystallization
Ko, S., Kim, H.Y., Choi, I., Choe, J.
Crystal Growth and Design, 2016, 17 (2), 497-503 Link
Dual effects of duplex RNA harboring 5′-terminal triphosphate on gene silencing and RIG-I mediated innate immune response
Baek, S.E., Kim, H., Kim, K.B., Yoon, S., Choe, J., Suh, W., Jeong, Y.-J., Cho, Y.H., Kim, D.-E.
Biochemical and Biophysical Research Communications, 2015, 456 (2), 591-597 Link
Structural and biochemical study of Bacillus subtilis HmoB in complex with heme
Park, S., Kim, D., Jang, I., Oh, H.B., Choe, J.
Biochemical and Biophysical Research Communications, 2014, 446 (1), 286-291 Link