University of Seoul
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Publications

Department of Life Science, UOS
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361. Pharmacological Inhibition of O-GlcNAc Transferase Promotes mTOR-Dependent Autophagy in Rat Cortical Neurons
Md Ataur Rahman, Yoonjeong Cho, Hongik Hwang, Hyewhon Rhim
Brain Sci, 10(12), 958, 10.3390/brainsci10120958 Link
360. Modulatory Effects of Autophagy on APP Processing as a Potential Treatment Target for Alzheimer's Disease
Md Ataur Rahman, Md Saidur Rahman, M D Hasanur Rahman, Mohammad Rasheduzzaman, Anm Mamun-Or-Rashid, Md Jamal Uddin, Md Rezanur Rahman, Hongik Hwang, Myung-Geol Pang, Hyewhon Rhim
Biomedicines, 9(1), 5, 10.3390/biomedicines9010005 Link
359. Hypoxia regulates allele-specific histone modification of the imprinted H19 gene
Yunwon Moon, Ingyum Kim, Seongyeol Lee, Soojeong Chang, Bongju Park, Seongwook Yoo, Sehyun Chae, Daehee Hwang, Hyunsung Park
BBA - Gene Regulatory Mechanisms, 1863(11), 194643, doi.org/10.1016/j.bbagrm.2020.194643 Link
358. HIF-1α-dependent Induction of Carboxypeptidase A4 and Carboxypeptidase E in Hypoxic Human Adipose-derived Stem Cells
Yunwon Moon, Ramhee Moon, Hyunsoo Roh, Soojeong Chang, Seongyeol Lee, Hyunsung Park
Molecules and Cells, 43(11), 945-952, doi.org/10.14348/molcells.2020.0100 Link
357. O-GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity.
Kim E, Kang JG, Kang MJ, Park JH, Kim YJ, Kim Y, Kweon TH, Lee HW, Jho EH, Lee Y, Kim SI, Yi EC, Park HW, Yang WH, Cho JW.
Proc Natl Acad Sci U S A., 117(25):1459-14269.,
356. MAML1/2 promote YAP/TAZ nuclear localization to enhance tumorigenesis.
Kim J, Kwon H, Shin YK, Song G, Lee T, Kim Y, Jeong W, Lee U, Zhang X, Nam G, Jeung HC, Kim W*, Jho EH*.
Proc Natl Acad Sci U S A., 117(24):13529-13540.,
355. The distinct role of Tcfs and Lef1 in the self-renewal or differentiation of mouse embryonic stem cells.
Kim S, Kim H, Tan A, Song Y, Lee H, Ying QL, Jho EH.
Int J Stem Cells., 13(2):192-201.,
354. LDL receptor-related protein LRP6 senses the level of nutrient and regulates Hippo signaling.
Jeong W, Kim S, Lee U, Zhong ZA, Savitsky M, Kwon H, Kim J, Lee T, Cho JW, Williams BO, Katanaev VL, Jho EH.
 EMBO Reports, 21(9);e50103,
353. TAZ/Wnt-β-catenin/c-MYC axis regulates cystogenesis in polycystic kidney disease.
Lee EJ, Seo E, Kim JW, Nam SA, Lee JY, Jun J, Oh S, Park M, Jho E, Yoo KH, Park JH, Kim YK.
Proc Natl Acad Sci U S A., 117(46);29001-29012,
352. Evidence for liver and peripheral immune cells secreting tumor-suppressive extracellular vesicles in melanoma patients
Jung-Hyun Lee, Martin Eberhardt, Katja Blume, Julio Vera, Andreas S Baur
EBioMedicine, 62, 103119, doi.org/10.1016/j.ebiom.2020.103119 Link
351. Comparison of diffusion-weighted MR imaging and 18F Fluorodeoxyglucose PET/CT in detection of residual/recurrent tumors and delineation of their spread after (chemo) radiotherapy for head and neck squamous cell carcinoma
Christophe Schroeder, Jung-Hyun Lee, Ulrich Tetzner, Stefan Seidel, Soung Yung Kim
European Journal of Radiology, 130, 109157, doi.org/10.1016/j.ejrad.2020.109157 Link
350. Neurotoxic potential of polystyrene nanoplastics in primary cells originating from mouse brain
Byung-Kwon Jung, Seung-Woo Han, So-Hyun Park, Jin-Sil Bae, Jinhee Choi, Kwon-Yul Ryu
Neurotoxicology, 81, 189–196, doi.org/10.1016/j.neuro.2020.10.008 Link
349. Simultaneous disruption of both polyubiquitin genes affects proteasome function and decreases cellular proliferation
Chul-Woo Park, Jin-Sil Bae, Kwon-Yul Ryu
Cell Biochemistry and Biophysics, 78(3), 321–329, doi.org/10.1007/s12013-020-00933-2 Link
348. Reduced free ubiquitin levels and proteasome activity in cultured neurons and brain tissues treated with amyloid beta aggregates
Chul-Woo Park, Byung-Kwon Jung, Kwon-Yul Ryu
Molecular Brain, 13(1), 89, doi.org/10.1186/s13041-020-00632-2 Link
347. Disruption of the polyubiquitin gene Ubb reduces the self-renewal capacity of neural stem cells
Chul-Woo Park, Byung-Kwon Jung, Kwon-Yul Ryu
Biochemical and Biophysical Research Communications, 527(2), 372–378, doi.org/10.1016/j.bbrc.2020.04.042 Link
346. Integrin αvβ3-Akt signalling plays a role in radioresistance of melanoma
Hyuntaik Im, Jeeyong Lee, Kwon-Yul Ryu, Jae Youn Yi
Experimental Dermatology, 29(6), 562-569, doi.org/10.1111/exd.14102 Link
345. Identification of Adverse Outcome Pathway related to High-Density PolyEthylene microplastics exposure: Caenorhabditis elegans transcription factor RNAi screening and zebrafish study
Youngho Kim, Jaeseong Jeong, Seungki Lee, Inhee Choi, Jinhee Choi
Journal of Hazardous Materials,  388, 121725, doi.org/10.1016/j.jhazmat.2019.121725 Link
344. Intracellular Nanomaterial Delivery via Spiral Hydroporation
GeoumYoung Kang, Daniel W. Carlson, Tae Ho Kang, Seungki Lee, Simon J. Haward, Inhee Choi, Amy Q. Shen, Aram J. Chung
ACS Nano, 14(3), 3048-3058, doi.org/10.1021/acsnano.9b07930 Link
343. Dual Mode Rapid Plasmonic Detections of Chemical Disinfectants (CMIT/MIT) Using Target-Mediated Selective Aggregation of Gold Nanoparticles
Tae Ho Kang, Chang Min Jin, Seungki Lee, Inhee Choi
Analytical Chemistry, 92(6), 4201-4208, doi.org/10.1021/acs.analchem.9b04081 Link
342. Graphene oxide-induced neurotoxicity on neurotransmitters, AFD neurons and locomotive behavior in Caenorhabditis elegans
Mina Kim, Hyun-Jeong Eom, Inhee Choi, Jongki Hong, Jinhee Choi
Neurotoxicology, 77, 30-39, doi.org/10.1016/j.neuro.2019.12.011 Link
341. Induction of crystal nucleation by orientation-controlled binding of His6-tagged proteins to functionalized gold nanoparticles
Jiyeon Park, Tae Ho Kang, Inhee Choi, Jungwoo Choe
CrystEngComm, 22(6), 1032-1040, doi.org/10.1039/C9CE01786K Link
340. Aqueous-Phase Synthesis of Hyaluronic Acid-based Hydrogel Nanoparticles for Molecular Storage and Enzymatic Release
Seungki Lee, Yunjeong Lee, Eun-Mi Kim, Kwang Woo Nam, Inhee Choi
ACS Applied Polymer Materials, 2(2), 342-350, doi.org/10.1021/acsapm.9b00834 Link
339. Adjustable and Versatile 3D Tumor Spheroid Culture Platform with Interfacial Elastomeric Wells
Hyun Ji An, Hyo Sil Kim, Jung A Kwon, Jihwan Song, Inhee Choi
ACS Applied Materials & Interfaces, 12(6), 6924-6932, doi.org/10.1021/acsami.9b21471 Link
338. Propionate of a microbiota metabolite induces cell apoptosis and cell cycle arrest in lung cancer.
Kwangkho Kim, Ohman Kwon, Tae Young Ryu, Cho-Rok Jung, Janghwan Kim, Jeong-Ki Min, Dae-Soo Kim, Mi-Young Son, Hyun-Soo Cho
Molecular medicine reports, 20, 1569-1574, 10.3892/mmr.2019.10431 Link
337. Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells.
Kwang Bo Jung, Ohman Kwon, Mi-Ok Lee, Hana Lee, Ye Seul Son, Omer Habib, Jung-Hwa Oh, Hyun-Soo Cho, Cho-Rok Jung, Janghwan Kim, Mi-Young Son
Journal of clinical medicine, 8, 10.3390/jcm8070976 Link
336. A SMN2 Splicing Modifier Rescues the Disease Phenotypes in an In Vitro Human Spinal Muscular Atrophy Model.
Ye Seul Son, Kwangman Choi, Hana Lee, Ohman Kwon, Kwang Bo Jung, Sunwha Cho, Jiyeon Baek, Bora Son, Sung-Min Kang, Mingu Kang, Jihee Yoon, Haihong Shen, Sangku Lee, Jung-Hwa Oh, Hyang-Ae Lee, Mi-Ok Lee, Hyun-Soo Cho, Cho-Rok Jung, Janghwan Kim, Sungchan Cho, Mi-Young Son
Stem cells and development, 28, 438-453, 10.1089/scd.2018.0181 Link
335. Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus
Hye-Yeoung Yun, Min Wook Kim, Hye Seon Lee, Wantae Kim, Ji Hye Shin, Hyunmin Kim, Ho-Chul Shin, Hwangseo Park, Byung-Ha Oh, Won Kon Kim, Kwang-Hee Bae, Sang Chul Lee, Eun-Woo Lee, Bonsu Ku, Seung Jun Kim
PLoS Biol., 10.1371/journal.pbio.3000367 Link
334. Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1
Wantae Kim, Yong Suk Cho, Xiaohui Wang, Ogyi Park, Xueyan Ma, Hanjun Kim, Wenjian Gan, Eek-Hoon Jho, Boksik Cha, Yun-Ji Jeung, Lei Zhang, Bin Gao, Wenyi Wei, Jin Jiang, Kyung-Sook Chung, Yingzi Yang
Proc Natl Acad Sci U S A., 10.1073/pnas.1821370116 Link
333. Developing scalable cultivation systems of hepatic spheroids for drug metabolism via genomic and functional analyses
Jiwon Ahn, Ho-Joon Lee, Soo Jin Oh, Wantae Kim, Seon Ju Mun, Jae-Hye Lee, Cho-Rock Jung, Hyun-Soo Cho, Dae-Soo Kim, Myung Jin Son, Kyung-Sook Chung
Biotechnol Bioeng., 10.1002/bit.26954 Link
332. Cationic amino acid transporter PQLC2 is a potential therapeutic target in gastric cancer
Yun-Ji Jeung, Kyeong Lee, Hyo Jin Lee, Eunah Kim, Myung Jin Son, Jiwon Ahn, Han-Gyeul Kim, Wantae Kim, Ho-Joon Lee, Jin Man Kim, Kyung-Sook Chung
Cancer Sci., 10.1111/cas.13966 Link
331. Crystal Structures of Putative Flavin Dependent Monooxygenase from Alicyclobacillus Acidocaldarius
Moon, H., Shin, S., Choe, J.
Crystals, 9 (11), 548, doi.org/10.3390/cryst9110548 Link
330. Gintonin Mitigates MPTP-Induced Loss of Nigrostriatal Dopaminergic Neurons and Accumulation of α-Synuclein via the Nrf2/HO-1 Pathway
Min Gi Jo, Muhammad Ikram, Myeung Hoon Jo, Lang Yoo, Kwang Chul Chung, Seung-Yeol Nah, Hongik Hwang, Hyewhon Rhim, Myeong Ok Kim
Mol Neurobiol, 56(1), 39-55, 10.1007/s12035-018-1020-1 Link
329. Gintonin, a Ginseng-Derived Exogenous Lysophosphatidic Acid Receptor Ligand, Protects Astrocytes from Hypoxic and Re-oxygenation Stresses Through Stimulation of Astrocytic Glycogenolysis
Sun-Hye Choi, Hyeon-Joong Kim, Hee-Jung Cho, Sang-Deuk Park, Na-Eun Lee, Sung-Hee Hwang, Ik-Hyun Cho, Hongik Hwang, Hyewhon Rhim, Hyoung-Chun Kim, Seung-Yeol Nah
Mol Neurobiol, 56(5), 3280-3294, 10.1007/s12035-018-1308-1 Link
328. Physical and Functional Interaction between 5-HT6 Receptor and Nova-1
Soon-Hee Kim, Misun Seo, Hongik Hwang, Dong-Min Moon, Gi Hoon Son, Kyungjin Kim, Hyewhon Rhim
Exp Neurobiol, 28(1), 17-29, 10.5607/en.2019.28.1.17 Link
327. Acutely elevated O-GlcNAcylation suppresses hippocampal activity by modulating both intrinsic and synaptic excitability factors
Hongik Hwang, Hyewhon Rhim
Sci Rep, 9(1), 7287, 10.1038/s41598-019-43017-9 Link
326. Deletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged mice
Hye Yun Kim, Yong Ryoul Yang, Hongik Hwang, Ha-Eun Lee, Hyun-Jun Jang, Jeongyeon Kim, Esther Yang, Hyun Kim, Hyewhon Rhim, Pann-Ghill Suh, Jae-Ick Kim
Sci Rep, 9(1), 17761, 10.1038/s41598-019-54477-4 Link
325. Ginseng Gintonin Enhances Hyaluronic Acid and Collagen Release from Human Dermal Fibroblasts Through Lysophosphatidic Acid Receptor Interaction
Rami Lee, Na-Eun Lee, Hongik Hwang, Hyewhon Rhim, Ik-Hyun Cho, Seung-Yeol Nah
Molecules, 24(24), 4438, 10.3390/molecules24244438 Link
324. Modulation of O-GlcNAcylation Regulates Autophagy in Cortical Astrocytes
Md Ataur Rahman, Hongik Hwang, Yoonjeong Cho, Hyewhon Rhim
Oxid Med Cell Longev, 2019, 6279313, 10.1155/2019/6279313 Link
323. The Cancer driver genes, IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: Crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism
Soojeong Chang, Sujin Yim & Hyunsung Park
Experimental And Molecular Medicine, 51(6), 01-17, doi.org/10.1038/s12276-019-0230-6 Link
322. Wnt3a disrupts GR-TEAD4-PPARγ2 positive circuits and cytoskeletal rearrangement in a β-catenin-dependent manner during early adipogenesis
Bongju Park, Soojeong Chang, Gwan-Jun Lee, Byeongsoo Kang, Jong Kyoung Kim & Hyunsung Park
Cell Death & Disease, 10(1), 16, doi.org/10.1038/s41419-018-1249-7 Link
321. Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1.
Kim W, Cho YS, Wang X, Park O, Ma X, Kim H, Gan W, Jho EH, Cha B, Jeung YJ, Zhang L, Gao B, Wei W, Jiang J, Chung KS, Yang Y.
Proc Natl Acad Sci U S A. , 116(19):9423-9432.,
320. A Concise Review of Human Brain Methylome During Aging and Neurodegenerative Diseases.
Prasad R and Jho EH.
BMB Rep., 52(10):577-588.,
319. Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity
William Riedl, Dhiraj Acharya, Jung-Hyun Lee, Guanqun Liu, Taryn Serman, Cindy Chiang, Ying Kai Chan, Michael S Diamond, Michaela U Gack
Cell Host Microbe, 26(4), 493-503, doiI: 10.1016/j.chom.2019.09.012 Link
318. Innate extracellular vesicles from melanoma patients suppress β-catenin in tumor cells by miRNA-34a
Jung-Hyun Lee, Jochen Dindorf, Martin Eberhardt, Xin Lai, Christian Ostalecki, Nina Koliha, Stefani Gross, Katja Blume, Heiko Bruns, Stefan Wild, Gerold Schuler, Julio Vera, Andreas S Baur
Life Science Alliance, 2(2), e201800205, doi: 10.26508/lsa.201800205 Link
317. Endogenous nucleic acid recognition by RIG-I-like receptors and cGAS
Jung-Hyun Lee, Cindy Chiang, Michaela U Gack
Journal of Interferon & Cytokine Research, 39(8), 450-458, doi.org/10.1089/jir.2019.0015 Link
316. Reversible regulation of polyubiquitin gene UBC via modified inducible CRISPR/Cas9 system
Seung-Woo Han, Byung-Kwon Jung, So-Hyun Park, Kwon-Yul Ryu
International Journal of Molecular Sciences, 20(13), 3168, doi.org/10.3390/ijms20133168 Link
315. Disruption of the polyubiquitin gene Ubb causes retinal degeneration in mice
Daehan Lim, Chul-Woo Park, Kwon-Yul Ryu, Hyewon Chung
Biochemical and Biophysical Research Communications, 513(1), 35–40, doi.org/10.1016/j.bbrc.2019.03.164 Link
314. Simultaneous profiling of 3D genome structure and DNA methylation in single human cells
Dong-Sung Lee, Chongyuan Luo, Jingtian Zhou, Sahaana Chandran, Angeline Rivkin, Anna Bartlett, Joseph R. Nery, Conor Fitzpatrick, Carolyn O’Connor, Jesse R. Dixon, Joseph R. Ecker
Nature Methods, 16, 999-1006, doi.org/10.1038/s41592-019-0547-z Link
313. Optical Detection of Small Metabolites for Biological Gas Conversion by using Metal Nanoparticle Monolayers Produced by Capillary-assisted Transfer
Keumrai Whang, Jeehan Chang, Kwangyeong Jung, Hyungduk Ko, Jungchul Lee, Inhee Choi, Taewook Kang
Analytical Chemistry, 91(20), 13152-13157, doi.org/10.1021/acs.analchem.9b03439 Link
312. Photothermally-Enhanced Molecular Delivery and Cellular Positioning on Patterned Plasmonic Interfaces
Tae Ho Kang, Seungki Lee, Jung A Kwon, Jihwan Song, Inhee Choi
ACS Applied Materials & Interfaces, 11(40), 36420-36427, doi.org/10.1021/acsami.9b13576 Link
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