분자세포생리학 실험실

Molecular Cellular Physiology Laboratory

Molecular Cellular Physiology Laboratory

University Of Seoul

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Welcome to Molecular Cellular Physiology Lab

Our lab investigates how hypoxia triggers gene expression, impacting metastasis, angiogenesis, senescence, cytoskeleton, and glycolysis. Diverse genes under hypoxia yield unique cell traits: hindered differentiation, reduced senescence, enhanced stemness, and resistance to anticancer therapy.
Decades of research have unveiled these intricate mechanisms. Our research topics are following
(1) Hypoxia, Cellular Senescence and Histone Demethylases
(2) Hypoxia, Adipogenesis, and Lipid Metabolism
(3) Inhibitors of Oxygen-Dependent Dioxygenases
(4) Signals Regulating HIF-1α and Oxygen-Dependent Dioxygenases

Latest Publications more +

Synergistic effect of Aloe vera flower and Aloe gel on cutaneous wound healing targeting MFAP4 and its associated signaling pathway: In-vitro study
Sultana Razia, Hyunsung Park, Eunju Shin, Kyu-Suk Shim, Eunae Cho, Min Chol Kang, Sun Yeou Kim
Journal of Ethnopharmacology, 2022, 290, 115096 Link
Gold and Silver plasmonic nanoprobes trace the position of histone codes
Inhee Choi Jiwhan Song, and Hyunsung Park
BMB reports, 2022, 55(3), 111-112 Link
Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia
Yunwon Moon, Sehyun Chae, Sujin Yim, Eun Gyeong Yang, Jungwoo Choe, Jiyeon Hyun, Rakwoo Chang, Daehee Hwang, Hyunsung Park
iScience, 2022, 25(7), 104517 Link
YAP-dependent Wnt5a induction in hypertrophic adipocytes restrains adiposity
Gwan-Jun Lee, Youn Ju Kim, Bongju Park, Sujin Yim, Chansang Park, Hyunsoo Roh, Yunwon Moon, Je Kyung Seong, Hyunsung Park
Cell death & disease, 2022, 13(4), 407 Link
High-spatial and colourimetric imaging of histone modifications in single senescent cells using plasmonic nanoprobes
Hyun Ji An, Yun Kim, Soojeong Chang, Hakchun Kim, Jihwan Song, Hyunsung Park, Inhee Choi
Nature Communications, 2021, 12(1), 5899 Link
Effects of Aloe vera Flower Extract and Its Active Constituent Isoorientin on Skin Moisturization via Regulating Involucrin Expression: In Vitro and Molecular Docking Studies
Sultana Razia, Hyunsung Park, Eunju Shin, Kyu-Suk Shim, Eunae Cho and Sun-Yeou Kim
Molecules, 2021, 26(9), 2626 Link
Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways
Seon Ah Lim, Yunwon Moon, Min Hwa Shin, Tae-Jin Kim, Sehyun Chae, Cassian Yee, Daehee Hwang, Hyunsung Park, Kyung-Mi Lee
Cancers, 2021, 13(8), 1904 Link
Hypoxia regulates allele-specific histone modification of the imprinted H19 gene
Yunwon Moon, Ingyum Kim, Seongyeol Lee, Soojeong Chang, Bongju Park, Seongwook Yoo, Sehyun Chae, Daehee Hwang, Hyunsung Park
BBA - Gene Regulatory Mechanisms, 2020, 1863(11), 194643 Link
HIF-1α-dependent Induction of Carboxypeptidase A4 and Carboxypeptidase E in Hypoxic Human Adipose-derived Stem Cells
Yunwon Moon, Ramhee Moon, Hyunsoo Roh, Soojeong Chang, Seongyeol Lee, Hyunsung Park
Molecules and Cells, 2020, 43(11), 945-952 Link
The Cancer driver genes, IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: Crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism
Soojeong Chang, Sujin Yim & Hyunsung Park
Experimental And Molecular Medicine, 2019, 51(6), 01-17 Link