Faculty

Our laboratory is conducting research utilizing a variety of sequencing technologies on the Genome, Epigenome, Transcriptome, and more. We focus on performing experiments and analyses using techniques such as Genome sequencing, RNA-seq, ChIP-seq, ATAC-seq, Hi-C seq, bisulfite-seq, and also on developing new technologies.

Experimental Method Development
We have developed and published single nucleus methyl 3C sequencing (snm3C-seq), a single-cell multimodal-omics technique that allows for the simultaneous observation of more than two features from a single cell (Nature Methods 2019). This was selected as the Technology of the Year in 2019 and is currently being used in the Brain Initiative project to study the brain's epigenetic profile.

Analysis Tool Development
We are developing analysis methods for various sequencing techniques. Among them, we have particularly studied Structural Variants (SVs) in cancer cells using Hi-C sequencing, and the resultant changes in the three-dimensional structure of the genome and their impact on gene expression, which was published in 2022 (Nature 2022).
In addition, we have developed all basic analysis pipelines for snm3C, which we previously developed, from the alignment stage, and we continue to develop programs for basic analysis (Nature Methods 2019).