생명정보학 실험실

Bioinformatics Laboratory

생명정보학 실험실

Bioinformatics Laboratory

Welcome to Bioinformatics Lab

Our laboratory is conducting research utilizing a variety of sequencing technologies on the Genome, Epigenome, Transcriptome, and more. We focus on performing experiments and analyses using techniques such as Genome sequencing, RNA-seq, ChIP-seq, ATAC-seq, Hi-C seq, bisulfite-seq, and also on developing new technologies.

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Latest Publications more +

Foxp3 Orchestrates Reorganization of Chromatin Architecture to Establish Regulatory T Cell Identity
Zhi Liu, Dong-Sung Lee, Yuqiong Liang, View ORCID ProfileYe Zheng, View ORCID ProfileJesse R Dixon
bioRxiv, 2023, Link
Epigenetic Regulations in Mammalian Cells: Roles and Profiling Techniques
Uijin Kim, Dong-Sung Lee
Molecules and Cells, 2023, 46(2), 86-98 Link
Species-specific environmental DNA analysis of the index species in soil ecosystem, Allonychiurus kimi (Collembola: Onychiuridae)
Yun-Sik Lee, Minhyung Jung, June Wee, Yongeun Kim, Doo-Hyung Lee, Dong-Sung Lee, Taewoo Kim, Kijong Cho, Cheolho Sim
Ecology and Evolution, 2022, 12(12), e9598 Link
Structural variants drive context-dependent oncogene activation in cancer
Zhichao Xu, Dong-Sung Lee, Sahaana Chandran, Victoria T. Le, Rosalind Bump, Jean Yasis, Sofia Dallarda, Samantha Marcotte, Benjamin Clock, Nicholas Haghani, Chae Yun Cho, Kadir C. Akdemir, Selene Tyndale, P. Andrew Futreal, Graham McVicker, Geoffrey M. Wahl, Jesse R. Dixon
Nature, 2022, 612, 564-572 Link
Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampus
Matthew G. Heffel, Jingtian Zhou, Yi Zhang, Dong-Sung Lee, Kangcheng Hou, Oier Pastor Alonso, Kevin Abuhanna, Anthony D. Schmitt, Terence Li, Maximilian Haeussler, Brittney Wick, Martin Jinye Zhang, Fangming Xie, Ryan S. Ziffra, View ORCID ProfileEran A. Mukamel, Eleazar Eskin, Bogdan Pasaniuc, Jos
bioRxiv, 2022, Link
Deciphering the Evolutionary History of Complex Rearrangements in Head and Neck Cancer Patients Using Multi-Omic Approach
Jeesoo Chae, Jin Seok Lee, Jongkeun Park, Dong-Sung Lee, Weon Seo Park, Benjamin Clock, Jesse R. Dixon, Yuh-Seog Jung, Dongwan Hong
bioRxiv, 2022, Link
Widespread somatic L1 retrotransposition in normal colorectal epithelium
Chang Hyun Nam, Jeonghwan Youk, Jeong Yeon Kim, Joonoh Lim, Jung Woo Park, Soo A Oh, Hyun Jung Lee, Ji Won Park, Seung-Yong Jeong, Dong-Sung Lee, Ji Won Oh, Jinju Han, Junehawk Lee, Hyun Woo Kwon, Min Jung Kim, Young Seok Ju
Nature, 2022, 617, 540-547 Link
Single nucleus multi-omics identifies human cortical cell regulatory genome diversity
Chongyuan Luo, Hanqing Liu, Fangming Xie, Ethan J. Armand, Kimberly Siletti, Trygve E. Bakken, Rongxin Fang, Wayne I. Doyle, Tim Stuart, Rebecca D. Hodge, Lijuan Hu, Bang-An Wang, Zhuzhu Zhang, Sebastian Preissl, Dong-Sung Lee, Jingtian Zhou, Sheng-Yong Niu, Rosa Castanon, Anna Bartlett, Angeline Ri
Cell Genomics, 2022, 2(3), 100107 Link
Hi-C as a molecular rangefinder to examine genomic rearrangements
Kyukwang Kim, Mooyoung Kim, Yubin Kim, Dongsung Lee, Inkyung Jung
Seminars in Cell & Developmental Biology, 2021, 121, 161-170 Link
Simultaneous profiling of 3D genome structure and DNA methylation in single human cells
Dong-Sung Lee, Chongyuan Luo, Jingtian Zhou, Sahaana Chandran, Angeline Rivkin, Anna Bartlett, Joseph R. Nery, Conor Fitzpatrick, Carolyn O’Connor, Jesse R. Dixon, Joseph R. Ecker
Nature Methods, 2019, 16, 999-1006 Link