Neurophysiology Laboratory

Department of Life Science, University of Seoul

Welcome to Neurophysiology Laboratory!

Our research focuses on the molecular mechanisms of synaptic plasticity underlying learning and memory.

Latest Publications more +

Lipid-enriched gintonin from Korean red ginseng marc alleviates obesity via oral and central administration in diet-induced obese mice
Tamanna Yasmin, Yuna Lee, Won Seok Kim, Bonggi Lee, Rami Lee, Hongik Hwang, Min-Ho Nam, Seung-Yeol Nah, Min Soo Kim, Hyewhon Rhim
Nutrients, 2025, 17(23), 3794 Link
Elevated O-GlcNAcylation enhances metabolic rate and reduces the excitability of hypothalamic ARC neurons in 10-month-old male mice
Tamanna Yasmin, Yuna Lee, Hongik Hwang, Jiyeon Seo, Min Soo Kim, Mikyoung Park, Soo-Jin Oh, Min-Ho Nam, Hyewhon Rhim
Exp Neurobiol, 2025, 34(4), 147-155 Link
Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice
Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi, Phuong Thi Thanh Nguyen, Uiyeol Park, Min-gyeong Kim, Hongik Hwang, Kyungeun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, Kayeong Lim, Hoon Ryu, Junghee Lee
Mol Neurodegener, 2025, 20, 16 Link
Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway
Jiyeon Seo, Hongik Hwang, Heesung Sohn, Eunsil Cho, Sunmin Jung, Soohyun Kim, Seung Min Um, Ji Yeon Kim, Muwon Kang, Yuri Choi, Jong-Hwan Kim, Mirang Kim, Seon-Young Kim, Sun-Kyung Lee, Joohong Ahnn, Hyewhon Rhim, Dong-Gyu Jo, Eunjoon Kim, Mikyoung Park
Mol Psychiatry, 2023, 28(3), 1351-1364 Link
Preparation of Red Ginseng Marc-Derived Gintonin and Its Application as a Skin Nutrient
Rami Lee, Ji-Hun Kim, Hongik Hwang, Hyewhon Rhim, Sung-Hee Hwang, Ik-Hyun Cho, Do-Geun Kim, Hyoung-Chun Kim, Seung-Yeol Nah
Nutrients, 2023, 15(11), 2574 Link
Visualization of the binding between gintonin, a Panax ginseng-derived LPA receptor ligand, and the LPA receptor subtypes and transactivation of the EGF receptor
Sun-Hye Choi, Ra Mi Lee, Han-Sung Cho, Sung Hee Hwang, Hong-Ik Hwang, Hyewhon Rhim, Hyoung-Chun Kim, Do-Geun Kim, Ik-Hyun Cho, Seung-Yeol Nah
J Ginseng Res, 2022, 46(3), 348-356 Link
Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer's Disease
Md Ataur Rahman, M D Hasanur Rahman, A N M Mamun-Or-Rashid, Hongik Hwang, Sooyoung Chung, Bonglee Kim, Hyewhon Rhim
Biomedicines, 2022, 10(5), 1027 Link
Myristoylation-dependent palmitoylation of cyclin Y modulates long-term potentiation and spatial learning
Jiyeon Seo, Hongik Hwang, Yuri Choi, Sunmin Jung, Jung-Hwa Hong, Bong-June Yoon, Hyewhon Rhim, Mikyoung Park
Prog Neurobiol, 2022, 218, 102349 Link
Cyclin Y, a novel actin-binding protein, regulates spine plasticity through the cofilin-actin pathway
Hongik Hwang, Young-Na Hur, Heesung Sohn, Jiyeon Seo, Jung-Hwa Hong, Eunsil Cho, Yuri Choi, Saebom Lee, Seongeun Song, A-Ram Lee, Suyeon Kim, Dong-Gyu Jo, Hyewhon Rhim, Mikyoung Park
Prog Neurobiol, 2021, 198, 101915 Link
Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome
Hongik Hwang, Matthew J Szucs, Lei J Ding, Andrew Allen, Xiaobai Ren, Henny Haensgen, Fan Gao, Hyewhon Rhim, Arturo Andrade, Jen Q Pan, Steven A Carr, Rushdy Ahmad, Weifeng Xu
Biol Psychiatry, 2021, 89(3), 256-269 Link