Faculty

[Development of In vitro biomimetic model system based on humanstem cells and organoids]

Our laboratory aims to precisely recapitulate complex biological phenomena and establish innovative therapeutic strategies for intractable diseases by utilizing human stem cell and organoid technologies. To achieve this, we are establishing robust protocols for the targeted differentiation and cultivation of human stem cells and organoids. Concurrently, we are developing high-efficiency transgenic technologies utilizing advanced gene-editing tools. These foundational efforts enable the construction of sophisticated biomimetic model systems capable of faithfully reproducing the intricate structural and functional architecture of actual human organs in vitro.

Furthermore, by leveraging these biomimetic platforms, we conduct in-depth investigations into physiological and pathophysiological molecular mechanisms. Ultimately, we seek to evaluate the efficacy of novel drug candidates with high translational fidelity, thereby contributing to the development of next-generation regenerative therapeutics with significant clinical applicability.

To fulfill these overarching objectives, our research focuses on the following specific domains:

(1) Development of differentiation and cultivation technologies for human stem cells and organoids
(2) Development of high-efficiency transgenic and genetic engineering technologies for human stem cells and organoids
(3) Construction of human stem cell- and organoid-based biomimetic model systems
(4) Elucidation of molecular mechanisms and discovery of novel therapeutics utilizing biomimetic model systems
(5) Development of next-generation regenerative therapeutics based on human stem cells and organoids