Welcome to Cellular Signal Transduction Lab

In our lab, we focus on elucidating the mechanisms behind how Wnt and Hippo signaling pathways are regulated to discover therapeutic targets of the diseases caused by abnormal regulation of these pathways. Wnt and Hippo signaling pathways were first studied as factors that take part in cancer development, early development of the body, or as a mechanism regulating organ size. Nowadays, as it was also found to have connections with apoptosis, NF-κB signaling, synaptogenesis, embryonic stem cell maintenance/differentiation, as well as Alzheimer’s disease, the fields of Wnt/Hippo signaling pathway are being studied with utmost attention around the world. We conduct experiments not only to clarify the regulatory mechanisms of Wnt and Hippo signaling pathways but also to broaden our view on involvement of these pathways to cancer development, regulation of embryonic stemness/ differentiation, and Alzheimer’s disease, using molecular biological techniques, mouse embryonic stem cells, primary neural cultures, organoids and transgenic mice etc.