세포신호전달실험실

서울시립대힉교 자연과학대학

Cellular Signal Transduction Laboratory

Department of Life Science, University Of Seoul

Research

Publications

Professor

Contact

Welcome to Cellular Signal Transduction Lab

In our lab, we focus on elucidating the mechanisms behind how Wnt and Hippo signaling pathways are regulated to discover therapeutic targets of the diseases caused by abnormal regulation of these pathways. Wnt and Hippo signaling pathways were first studied as factors that take part in cancer development, early development of the body, or as a mechanism regulating organ size. Nowadays, as it was also found to have connections with apoptosis, NF-κB signaling, synaptogenesis, embryonic stem cell maintenance/differentiation, as well as Alzheimer’s disease, the fields of Wnt/Hippo signaling pathway are being studied with utmost attention around the world. We conduct experiments not only to clarify the regulatory mechanisms of Wnt and Hippo signaling pathways but also to broaden our view on involvement of these pathways to cancer development, regulation of embryonic stemness/ differentiation, and Alzheimer’s disease, using molecular biological techniques, mouse embryonic stem cells, primary neural cultures, organoids and transgenic mice etc.

Latest Publications more +

Targeting a chemo-induced adaptive signaling circuit confers therapeutic vulnerabilities in pancreatic cancer.
Saito Y, Xiao Y, Yao J, Li Y, Liu W, Yuzhalin AE, Shyu YM, Li H, Yuan X, Li P, Zhang Q, Li Z, Wei Y, Yin X, Zhao J, Kariminia SM, Wu YC, Wang J, Yang J, Xia W, Sun Y, Jho EH, Chiao PJ, Hwang RF, Ying H, Wang H, Zhao Z, Maitra A, Hung MC, DePinho RA, Yu D.
Cell Discov., 2024, 10(1):109.,
Retinoic acid-induced protein 14 links mechanical forces to Hippo signaling.
Jeong W, Kwon H, Park SK, Lee IS, Jho EH.
EMBO Rep. , 2024, 25: 4033 - 4061,
Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress. Autophagy. 2023 Jan 31. doi: 10.1080/15548627.2023.2173900. Online ahead of print.
Thao Thi Dang, Mi-Jeong Kim, Yoon Young Lee, Hien Thi Le, Kook Hwan Kim, Somi Nam, Seung Hwa Hyun, Hong Lim Kim, Su Wol Chung, Hun Taeg Chung, Jho EH, Hiderou Yoshida, Kyoungmi Kim, Chan Young Park, Myung-Shik Lee, Sung Hoon Back.
Autophagy, 2023, 19(7); 2111–2142,
Regulation of Hippo signaling by metabolic pathways in cancer.
Lee U, Cho E, Jho EH.
Biochim Biophys Acta Mol Cell Res., 2022, 1869(4);119201,
Past, Present, and Future Perspectives of Transcription Factor EB (TFEB): Mechanisms of regulation and association with disease.
Tan A*, Prasad R*, Lee C, and Jho EH.
Cell Death Differ., 2022, 29(8);14331449,
O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway.
Kim E, Kang JG, Jho EH, Yang WH, Cho JW.
Cancers (Basel)., 2022, 14(12):3013,
Systemic TM4SF5 overexpression in Apc Min/+ mice promotes hepatic portal hypertension associated with fibrosis
Lee J, Kim E, Kang MK, Ryu J, Kim JE, Shin EA, Pinanga Y, Pyo KH, Lee H, Lee EH, Cho H, Cheon J, Kim W, Jho EH, Kim S, Lee JW.
BMB Rep., 2022, 55(12);609-614,
SGK1 inhibition in glia ameliorates pathologies and symptoms of Parkinson's disease.
Kwon O, Song J, Yang Y, Kim S, Kim J, SeoK M, Hwang I, Yu J, Jenisha K, Maeng H, Kim J, Jho EH, Ko S, Son H, Chang M, Lee S.
EMBO Mol Med., 2021, 13(4);e13076,
LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways.
Jang J, Song J, Lee H, Sim I, Kwon YV, Jho EH*, and Yoon Y*.
Exp Mol Med., 2021, 53(3);407-421,
PARsylated transcription factor EB (TFEB) regulates the expression of a subset of Wnt target genes by forming a complex with β-catenin-TCF/LEF1.
Kim S, Song G, Lee T, Kim M, Kwon H, Kim J, Jeong W, Lee U, Na C, Kang S, Kim W, Seong J, and Jho EH.
Cell Death Differ., 2021, 28(9);2555-2570,