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Viral Immunology Laboratory

Viral Immunology Laboratory

University Of Seoul

Welcome to Viral Immunology Lab

“Decoding the Complex Interplay of Host-Virus Interactions”

We are dedicated to unraveling the intricate dynamics that govern the interactions between hosts and viruses, and their profound implications for human health and disease. Host-virus interactions form a fascinating and complex battleground where the delicate balance between invading viruses and the host immune defenses shapes the outcome of infections. The interplay between a viral pathogen and its host organism involves a myriad of intricate molecular and cellular processes that govern viral entry, replication, immune evasion, and host immune activation. Understanding the underlying mechanisms driving these interactions is paramount for advancing our knowledge of virology and developing effective strategies to combat viral infections.

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Latest Publications more +

Diagnostic value of 18F-FDG PET/CT versus diffusion-weighted MRI in detection of residual or recurrent tumors after definitive (chemo) radiotherapy for laryngeal and hypopharyngeal squamous cell carcinoma: A prospective study
Soung Yung Kim, David Crook, Johannes Rosskopf, Jung-Hyun Lee
Head Neck, 2024, Link
The Role of Extracellular Vesicles in Pandemic Viral Infections
Woosung Shim, Anjae Lee, Jung-Hyun Lee
Journal of Microbiology, 2024, Link
The complex role of extracellular vesicles in HIV infection
Jung-Hyun Lee
BMB Reports, 2023, 56, 335-340 Link
Endogenous IFITMs boost SARS-coronavirus 1 and 2 replication whereas overexpression inhibits infection by relocalizing ACE2
Qinya Xie, Caterina Prelli Bozzo, Laura Eiben, Sabrina Noettger, Dorota Kmiec, Rayhane Nchioua, Daniela Niemeyer, Meta Volcic, Jung-Hyun Lee, Fabian Zech , Konstantin M J Sparrer, Christian Drosten, Frank Kirchhoff
iScience, 2023, 26(4), 106395 Link
Interferon antagonists encoded by SARS-CoV-2 at a glance
Jung-Hyun Lee , Lennart Koepke, Frank Kirchhoff, Konstantin M J Sparrer
Medical Microbiology and Immunology, 2023, 212(2), 125-131 Link
Magnetic resonance imaging of parotid gland tumors: a pictorial essay
Soung Yung Kim, Urs Borner, Jung-Hyun Lee, Franca Wagner, Dechen W Tshering Vogel
BMC Med Imaging, 2022, 22(1), 191 Link
Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus
Jung-Hyun Lee, Christian Ostalecki, Timo Oberstein, Stefan Schierer, Elisabeth Zinser, Martin Eberhardt, Katja Blume, Bianca Plosnita, Lena Stich, Heiko Bruns, Roland Coras, Julio Vera-Gonzales, Manuel Maler, Andreas S Baur
EBioMedicine, 2022, 77, 103903 Link
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.
GuanQun Liu*, Jung-Hyun Lee*, Zachary M. Parker, Dhiraj Acharya, Jessica J. Chiang, Michiel van Gent, William Riedl, Meredith E. Davis-Gardner, Effi Wies, Cindy Chiang & Michaela U. Gack
Nature Microbiology, 2021, 6, 467-478 Link
The BRCA1 Pseudogene Negatively Regulates Antitumor Responses through Inhibition of Innate Immune Defense Mechanisms
Yoo Jane Han, Jing Zhang, Jung-Hyun Lee, Jennifer M Mason, Olga Karginova, Toshio F Yoshimatsu, Qinyu Hao, Ian Hurley, Laia Paré Brunet, Aleix Prat, Kannanganattu V Prasanth, Michaela U Gack, Olufunmilayo I Olopade
Cancer Research, 2021, 81(6), 1540-1551 Link
Evidence for liver and peripheral immune cells secreting tumor-suppressive extracellular vesicles in melanoma patients
Jung-Hyun Lee, Martin Eberhardt, Katja Blume, Julio Vera, Andreas S Baur
EBioMedicine, 2020, 62, 103119 Link